Molecular Biology of Keratinocyte Differentiation
نویسندگان
چکیده
منابع مشابه
Molecular biology of keratinocyte differentiation.
Epidermal keratinocytes (skin cells) are highly specialized epithelial cells designed to perform a very specific function, separation of the organism from its environment. To accomplish this the cells synthesize precursors and assemble them into two distinct structures, the cornified envelope and keratin intermediate filaments. The intermediate filaments are assembled from keratin monomers and ...
متن کاملMolecular biology and biochemistry of differentiation.
Recent work in the field of molecular biology and differentiation has been directed towards an assessment of the number of different genes involved in the development and differentiation process. By the techniques of RNA-DNA hybridization to single copy DNA, it appears that some 60,000-200,000 different RNA sequences are expressed during embryonic development in the mouse. The differentiating b...
متن کاملSIRT3 regulation of keratinocyte differentiation
Background: SIRT3 plays a major role in protecting against mitochondrial oxidative stress. Results: Oxidative stress increases during keratinocyte differentiation, and SIRT3 can decrease differentiation by attenuating oxidative stress. Conclusion: SIRT3-induced down regulation of mitochondrial oxidative stress attenuates keratinocyte differentiation. Significance: Understanding the regulation o...
متن کاملThe keratinocyte growth-differentiation switch.
Growth/differentiation control of normal epithelial cells has been relatively understudied, because of the complexities involved in their cultivation and characterization. The present review is focused on progress in this area using the mouse primary keratinocyte system. This system reproduces under well defined culture conditions the switch between epithelial cell growth and differentiation wh...
متن کاملE2F Modulates Keratinocyte Squamous Differentiation
E2F regulation is essential for normal cell cycle progression. Therefore, it is not surprising that squamous cell carcinoma cell lines (SCC) overexpress E2F1 and exhibit deregulated E2F activity when compared with normal keratinocytes. Indeed, deliberate E2F1 deregulation has been shown to induce hyperplasia and skin tumor formation. In this study, we report on a dual role for E2F as a mediator...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1989
ISSN: 0091-6765
DOI: 10.2307/3430736